Research progress of exosomes derived from mesenchymal stromal cells in the prevention and treatment of hypertrophic scar

VernacularTitle:间充质基质细胞来源外泌体在增生性瘢痕防治中的研究进展
Author: Han LUO ¹ ; Fang QI ; Dali WANG
Author Information

1. 遵义医科大学附属医院烧伤整形外科　563003
Keywords: Mesenchymal stromalcells; Extracellular vesicles; Exosomes; Cicatrix, hypertrophic; Fibrosis
From: Chinese Journal of Plastic Surgery 2021;37(11):1276-1281
CountryChina
Language:Chinese
Abstract: Hypertrophic scar (HS) with complications of pain, pruritus, deformity and dysfunction substantially affects people’s mental health and the quality of life. Currently, despite the diversity of treatment options for HS, their efficacies remain suboptimal. Recently, a great deal of research focuses on the therapeutic potential of exosomes derived from mesenchymal stromal cells(MSCs-Exo), and related therapies are also being extensively investigated. The review expounded the pathophysiological changes and molecular mechanism of HS, and summarized the mode of action and the research progress of exosomes in the prevention and treatment of HS, which derived from MSCs originate from fat, bone marrow, umbilical cord, umbilical cord blood, amniotic membrane and amniotic fluid, so as to provide new ideas for the prevention and treatment of HS.