Research progress of pyroptosis in tumor development and anti-tumor immunity
10.3760/cma.j.cn112152-20201009-00883
- VernacularTitle:细胞焦亡与肿瘤的发生发展及抗肿瘤免疫
- Author:
Kexin LI
1
;
Wei CUI
Author Information
1. 国家癌症中心 国家肿瘤临床医学研究中心 中国医学科学院北京协和医学院肿瘤医院检验科，北京 100021
- Keywords:
Neoplasms;
Pyroptosis;
Gasdermin;
Anti-tumor immunity
- From:
Chinese Journal of Oncology
2022;44(8):815-819
- CountryChina
- Language:Chinese
-
Abstract:
Pyroptosis, a pro-inflammatory programmed cell death, is different from apoptosis and necroptosis, which is characterized by the activation of inflammasome and caspase family members and the cleavage of gasdermin family members, resulting in pores in the cell membrane accompanied by the release of inflammatory cytokines and a series of inflammatory reactions. Pyroptosis has a dual effect on tumors: on one hand, pyroptosis can inhibit tumor growth; on the other hand, a series of inflammatory responses triggered by excessively activated pyroptosis increase the risk of tumorigenesis. Pyroptosis can activate anti-tumor immune responses and induce pyroptosis in patients with low immune activity or no response to other immunotherapies, which has certain application prospects for tumor therapy.
