Research progress on pollution status and toxic effects of organophosphorus flame retardants 2-ethylhexyl diphenyl phosphate
10.3760/cma.j.cn121094-20230119-00019
- VernacularTitle:有机磷阻燃剂2-乙基己基二苯基磷酸酯的污染现状及毒性效应研究进展
- Author:
Xueyan ZHANG
1
;
Tianwei ZHANG
;
Jing LI
Author Information
1. 江苏医药职业学院公共卫生与管理学院，盐城 224005
- Keywords:
Environmental exposure;
Organophosphate esters;
Flame retardants;
2-ethylhexyl diphenyl phosphate;
Toxic effect;
Occupational exposure
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2024;42(3):224-231
- CountryChina
- Language:Chinese
-
Abstract:
The environmental pollution and health hazards caused by the extensive use of organophosphorus flame retardants (OPFRs) have become a problem of wide concern around the world. As a typical OPFR, 2-ethylhexyl diphenyl phosphate (EHDPP) can be detected in water, atmosphere, soil and other environmental media. It widely exists in production and life and can accumulate in organisms, causing great risks the ecosystem and human health. This paper reviews the research of EHDPP domestically and abroad, and summarizes the physicochemical properties of EHDPP and the population situation of occupational exposure, environmental exposure, and population exposure in recent years. Besides, it summarizes the toxic effects and mechanisms of EHDPP, including acute toxicity, hepatotoxicity, neurotoxicity, reproductive and developmental toxicity, and carcinogenesis effects. This paper also proposes the future direction of toxicity and health risks of EHDPP, which provides a theoretical basis for further research on environmental hazards and safety evaluation of EHDPP.
