Correlation between prognostic nutritional index and pleural thickness with survival time of epithelial malignant pleural mesothelioma patients
10.3760/cma.j.cn121094-20230106-00011
- VernacularTitle:预后营养指数及胸膜厚度与上皮型恶性胸膜间皮瘤患者生存时间的相关性研究
- Author:
Jianhong ZHOU
1
;
Yanli ZHANG
;
Lifeng LI
;
Peiling LU
Author Information
1. 云南省楚雄彝族自治州人民医院胸心外科，楚雄 675000
- Keywords:
Mesothelioma;
Epithelial;
Malignant;
Pleural;
Prognostic nutritional index;
Pleural thickness;
Prognosis
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2024;42(2):118-123
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the role of prognostic nutritional index (PNI) and pleural thickness in the prognostic evaluation of patients with epithelial malignant pleural mesothelioma (MPM) .Methods:In April 2022, a retrospective analysis was conducted on the data and laboratory data of 41 patients with epithelial MPM admitted to the cardiothoracic surgery department of Chuxiong Yi Autonomous Prefecture People's Hospital from January 2018 to May 2021. Univariate and multivariate analysis were used to evaluate the relationships between total survival time, clinical characteristics, PNI and pleural thickness in patients.Results:The 41 patients were mostly male (26 cases, 63.4%) , with a median age of 55 years old. The main clinical manifestations were chest pain (53.7%) , bloody pleural effusion (75.6%) , and chest pain combined with bloody pleural effusion (36.6%) . The median survival time of patients with different TNM stage, efficacy after 4 cycles of chemotherapy, PNI, maximum pleural thickness after chemotherapy (post max) , sum of post max in 3 zones after chemotherapy (post sum) were statistically different (χ 2=3.89, 14.51, 15.33, 4.33, 12.05, P<0.05) . Compared with patients with high PNI and post sum<32.26 mm, MPM patients with low PNI and post sum≥32.26 mm have higher risk of death, and the differences were statistically significant ( HR=1.52, 95% CI: 1.75-11.93, P=0.002; HR=1.70, 95% CI: 1.84-16.23, P=0.002) . Conclusion:PNI and post sum can be used to predict the prognosis of patients with epithelial MPM.
