Determination of platinum anticancer drugs in occupational settings by ICP-MS
10.3760/cma.j.cn121094-20220222-00083
- VernacularTitle:职业环境中铂类抗癌药物测定的感应耦合等离子体质谱法
- Author:
Yiran LIN
1
;
Xiaohong MEI
;
Xiaohong HUANG
;
Tiandi LI
;
Yi LIN
;
Wen ZHANG
Author Information
1. 深圳市职业病防治院理化检测所，深圳 518020
- Keywords:
ICP-MS, Environmental table;
Environment;
Object surface;
Platinum antineoplastic drugs
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2022;40(12):950-951
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To establish an inductively coupled plasma mass spectrometry (ICP-MS) for platinum antineoplastic drugs in the environment.Methods:The platinum antineoplastic drugs in the environmental table were eluted by wiping and collecting pure water, and the supernatant was taken by centrifugation and inductively coupled plasma mass spectrometry for detection.Results:The concentration range of 0-8.0 μg/L was good, the correlation coefficient was 1.000, the detection limit was 0.0006 μg/L, the lower quantitative limit was 0.002 μg/L, the method precision was between 0.9%-1.3%, and the sample standard recovery rate was between 97.0%-98.5%.Conclusion:This method has low detection limit, high accuracy and precision, and simple sample pretreatment, which is suitable for the determination of platinum antineoplastic drugs in environmental tables.
