Research progress on cardiac developmental toxicity induced by environmental endocrine disruptors exposure
10.3760/cma.j.cn121094-20210615-00290
- VernacularTitle:环境内分泌干扰物暴露引起心脏发育毒性的研究进展
- Author:
Xiaolian YANG
1
;
Jie XU
;
Jie YU
Author Information
1. 遵义医科大学公共卫生学院劳动卫生与环境卫生教研室，遵义 563006
- Keywords:
Environmental pollutants;
Endocrine disruptors;
Cardiac developmental toxicity;
Cardiac morphology and structure;
Cardiac function
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2022;40(7):552-557
- CountryChina
- Language:Chinese
-
Abstract:
Environmental endocrine disruptors (EDCs) are ubiquitous in the environment, and detectable amounts are found in humans worldwide. EDCs can interact with nuclear receptors such as estrogen receptor, which could interfere with the normal function of endocrine system, and further cause the pathological alterations in the tissues. This article summarizes several common types of EDCs in the environment, which caused cardiac function abnormalities, and morphological growth malformations in heart as well as its relevant mechanisms, including oxidative stress, inflammatory response, changes in signal transduction, expressions of transcriptional regulatory factors, which are related to cardiac development, receptor pathways and cell apoptosis etc., for the purpose of understanding the process of EDCs-induced cardiac developmental toxicity, and further providing scientific theoretical basis for figuring out the toxicity mechanism of EDCs and the prevention and treatment of cardiac diseases.
