Research progress on the effect of selective autophagy receptor p62 on fibrotic diseases
10.3760/cma.j.cn121094-20201218-00699
- VernacularTitle:选择性自噬受体p62对纤维化疾病影响的研究进展
- Author:
Shang YANG
1
;
Shiyi TAN
;
Shi CHEN
Author Information
1. 410000 长沙，湖南师范大学医学院
- Keywords:
Fibrotic;
p62;
Selective autophagy;
Lung fibrotic;
Liver fibrosis;
Kidney fibrosis
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2021;39(10):797-800
- CountryChina
- Language:Chinese
-
Abstract:
Selective autophagy keeps cell homeostasis by degrading aggregated proteins, damaged or over-abundant organelles, and other cytoplasmic substances. The maintenance of its normal function needs to ensure that the autophagy receptor can effectively recognize and isolate undegraded substances. As an important autophagy receptor protein, p62 participates in the process of selective autophagy by mediating multiple signaling pathways. Fibrosis is a pathological feature of most chronic inflammatory diseases. When fibrosis develops for a long time, it will cause substantial scar formation and eventually lead to cell dysfunction and organ failure. The accumulation, overexpression and ectopic expression of p62 can aggravate the occurrence and development of lung, liver and kidney fibrosis diseases. Therefore, it is very critical to explore the effect of selective autophagy receptor p62 on fibrotic diseases.
