Effects of Rhodiola rosea injection on intrapulmonary shunt and blood IL-6 and TNF-α levels during single lung ventilation in patients undergoing radical resection of esophageal cancer
10.12122/j.issn.1673-4254.2024.04.12
- VernacularTitle:红景天注射液降低食管癌根治术患者单肺通气期间肺内分流及血清炎症介质:46例随机对照试验
- Author:
Xi LIU
1
;
Huan HU
;
Jing FANG
;
Lu HUANG
;
Xiangyang CHENG
Author Information
1. 蚌埠医科大学第一附属医院麻醉科,安徽 蚌埠 233000
- Keywords:
Rhodiola;
esophageal cancer;
single lung ventilation;
hypoxic pulmonary vasoconstriction
- From:
Journal of Southern Medical University
2024;44(4):706-711
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of Rhodiola rosea injection on pulmonary shunt and serum interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) levels during single lung ventilation in patients undergoing radical resection of esophageal cancer. Methods Forty-six patients undergoing radical operation for esophageal cancer were randomized equally into control group and Rhodiola rosea injection group. In the Rhodiola group, 10 mL of Rhodiola rosea injection was added into 250 mL of normal saline or 5％ glucose solution for slow intravenous infusion, and normal saline of the same volume was used in the control group after the patients entered the operation room. At T0, T1 and T3, PaO2 of the patient was recorded and 2 mL of deep venous blood was collected for determination of serum TNF-α and IL-6 levels. The incidence of postoperative atelectasis of the patients was recorded. Results Compared with those in the control group, the patients receiving Rhodiola rosea injection had significantly higher PaO2 and Qs/Qt at T1 and T2 (P<0.05) and lower serum IL-6 and TNF-α levels at T3 (P<0.05). No significant difference in the incidence of postoperative atelectasis was observed between the two groups (P>0.05). Conclusion Rhodiola rosea injection before anesthesia induction can reduce intrapulmonary shunt during single lung ventilation, improve oxygenation, reduce serum IL-6 and TNF-α levels, and alleviate intraoperative lung injury in patients undergoing radical resection of esophageal cancer.
