Effect of statins on occurrence of infection and infection-related mortality:a meta-analysis

VernacularTitle:他汀类药物与感染发生率及死亡率关系的meta分析
Author: Guizuo WANG ¹ ; Yonghong ZHANG ; Xinming XIE ; Dong HAN ; Yuanyuan WU ; Shaojun LI ; Fengjuan LI ; Manxiang LI
Author Information

1. 西安交通大学第二附属医院呼吸病研究室/呼吸内科
Keywords: statins; risk of infection; infection-related mortality; randomized controlled trials; meta-analysis
From: Journal of Southern Medical University 2014;(7):988-993
CountryChina
Language:Chinese
Abstract: Objective To systematically review whether statins can reduce the risk of infection and infection-related mortality. Methods We searched the Cochrane Library, MEDLINE, EMBASE, PubMed, Elsevier and CBM databases for randomized placebo-controlled trials of statins published by September 2013, and each trial enrolled at least 100 participants with follow-up for at least 4 weeks. Two reviewers independently assessed the quality of the included studies and extracted the relevant data for analysis using Stata 12.0 software. Results Sixteen trails involving a total of 48973 patients were included in our meta-analysis. The results showed that statins significantly reduced the risk of infection (OR=0.93, 95% CI 0.89 to 0.98, P=0.004) compared to placebo but did not significantly lower infection-related mortality (OR=0.96, 95% CI 0.82 to 1.12, P=0.592). Conclusion Statins can significantly reduce the risk of infection but does not lower infection-related mortality.