Role of Wnt/β-catenin signaling pathway in promoting tumorigenesis of hepatocellular car-cinoma
10.3969/j.issn.1673-4254.2014.06.32
- VernacularTitle:Wnt/β-catenin信号通路在肝细胞癌中的促进作用
- Author:
Lianghai XIE
1
;
Han JIANG
;
Fusheng WU
Author Information
1. 宁波市北仑区中医院
- Keywords:
hepatocellular carcinoma;
Wnt/β-catenin signaling pathway;
hepatitis B virus;
hepatitis C virus
- From:
Journal of Southern Medical University
2014;(6):913-917
- CountryChina
- Language:Chinese
-
Abstract:
Wnt/β-catenin signaling pathway has a close relationship with cancer and is abnormally activated in many human cancers. Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related death worldwide, but the molecular mechanisms of HCC are still poorly understood. Current studies indicate that Wnt/β-catenin signaling pathway plays a key role in the development and progression of HCC. Validating the role and mechanism of Wnt/β-catenin signaling pathway in HCC will provide a theoretical basis for early diagnosis and treatment of HCC. In this review, we summarize the role of Wnt/β-catenin signaling pathway in HCC and the progress of current researches.
