Current research status of virus-like particle vaccine

VernacularTitle:病毒样颗粒疫苗研究进展
Author: Lei ZHANG ¹ ; Yifan YANG ; Xi MA ; Yongfeng ZHANG ; Yang WANG
Author Information

1. 西安医学院基础医学部　西安市病原微生物与肿瘤免疫重点实验室，西安　710021
Keywords: Virus-like particle vaccine; Immune response; Protein nanoparticles
From: Chinese Journal of Preventive Medicine 2024;58(9):1404-1414
CountryChina
Language:Chinese
Abstract: Virus-like particles (VLPs) are self-assembled protein nanoparticles with repetitive antigen epitopes, which can stimulate immune response and do not contain viral genetic materials. VLPs has important research value and application potential in vaccine development, targeted drug delivery and bioengineering materials. In this review, the mechanism of VLPs vaccine induced immune responses is discussed. The existing VLPs expression systems are summarized. The research progress of VLPs vaccine in prevention and treatment of virus infection are summarized. This review provides general reference and guidance for the design and development of antiviral VLPs vaccine.