Research status and reflection on animal models of sepsis
10.3760/cma.j.cn112150-20230926-00225
- VernacularTitle:脓毒症动物模型研究现状及思考
- Author:
Qing YE
1
;
Shiqiang SHANG
Author Information
1. 浙江大学医学院附属儿童医院实验检验中心，杭州 310052
- Keywords:
Sepsis;
Animal model;
Clinical transformation
- From:
Chinese Journal of Preventive Medicine
2024;58(2):171-176
- CountryChina
- Language:Chinese
-
Abstract:
Infectious diseases are the leading cause of death in children. Sepsis is a critical infectious disease that causes death in children globally, with a high morbidity and mortality rate. It poses a serious threat to children′s health. Early diagnosis has become the key to treating severe sepsis. The establishment of animal models of sepsis can help people better diagnose sepsis and take interventions to improve the prognosis of sepsis patients. This study reviews the types, advantages and disadvantages of existing animal models of sepsis and proposes the optimization of these models to provide a reference basis for the selection and optimization of experimental models and the promotion of the "reverse transformation" of sepsis into clinical practice.
