On detection of chromogranin A, synaptophysin, neuronspecific enolase and progastrin-releasing peptide in small cell lung cancer
10.3760/cma.j.cn112150-20220106-00022
- VernacularTitle:小细胞肺癌中嗜铬粒蛋白A与突触素和神经元特异性烯醇化酶及胃泌素释放肽前体检测的研究进展
- Author:
Qingqing LU
1
;
Jing LI
;
Yunhao LI
;
Hua LIU
;
Xiaobing XIE
Author Information
1. 湖南中医药大学第一附属医院医学检验与病理中心，长沙 410007
- Keywords:
Small-cell lung cancer;
Chromogranin A;
Synaptophysin;
Neuronspecific enolase;
Progastrin-releasing peptide
- From:
Chinese Journal of Preventive Medicine
2022;56(7):1017-1022
- CountryChina
- Language:Chinese
-
Abstract:
Lung cancer is one of the most common cancer, there is a significant difference between the treatment and prognosis of small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). SCLC tumor cells usually express neuroendocrine tumor (NET) markers, among which there are many studies on chromogranin A (CgA), synaptophysin (Syn), neuronspecific enolase (NSE) and pro-gastrin-releasing peptide (Pro-GRP) with SCLC. The levels of CgA, NSE and pro-GRP were related to the stage of SCLC, which were significantly higher in patients with extensive stage than in patients with limited stage, and their expression was significantly correlated with lower survival rate. Syn as an auxiliary diagnostic index of SCLC is more sensitive than CgA, and has high practical value in the differential diagnosis of SCLC and poorly differentiated squamous cell carcinoma; NSE is the most commonly used tumor marker in SCLC; Pro-GRP has stronger diagnostic advantages than CEA and NSE in distinguishing SCLC from NSCLC. Although these net markers are not specific markers of SCLC, their combined use with each others or combined with CT as an auxiliary diagnostic index may improve the level of differential diagnosis of SCLC, and they have a certain value in the staging of the disease, which is very important for the formulation of SCLC treatment strategy, their detection is conducive to the prevention and control of the disease.
