Research progress on the effects of sodium-glucose linked transporter 2 inhibitors on multiple metabolic disorders in metabolic syndrome
10.3724/zdxbyxb-2023-0585
- VernacularTitle:钠-葡萄糖耦联转运体2抑制剂对代谢综合征相关代谢紊乱的作用研究进展
- Author:
Chunxiang XU
1
;
Xiaoxia CAI
;
Xingyu QIU
;
Liang ZHAO
Author Information
1. 浙江大学医学院附属儿童医院肾内科 国家儿童健康与疾病临床医学研究中心,浙江 杭州 310052
- Keywords:
Sodium-glucose linked transporter 2 inhibitors;
Metabolic syndrome;
Diabetes mellitus;
Weight loss;
Hypertension;
Dyslipidemia;
Hyperuricemia;
Review
- From:
Journal of Zhejiang University. Medical sciences
2024;53(3):382-389
- CountryChina
- Language:Chinese
-
Abstract:
Metabolic syndrome is a complex group of metabolic disorders with an increasing global incidence rate,posing a serious threat to human health.Sodium-glucose linked transporter 2(SGLT2)inhibitors are a new type of oral hypoglycemic drug.SGLT2 inhibitors not only lower blood glucose level in a non-insulin-dependent manner by inhibiting glucose reabsorption by renal proximal convoluted tubular epithelial cell to promote urinary glucose excretion,but also by improving islet β cell function,reducing inflammatory responses,and inhibiting oxidative stress.In addition,SGLT2 inhibitors can reduce body weight through osmotic diuresis and increase fat metabolism;reduce blood pressure by inhibiting excessive activation of sympathetic nervous system and by improving vascular function.They can also improve blood lipids by increasing degradation of triacylglycerol;reduce blood uric acid by promoting uric acid excretion in kidney and intestine,and by reducing uric acid synthesis.This article reviews the effects and mechanisms of SGLT2 inhibitors on multiple metabolic disorders in metabolic syndrome and explores their potential application in metabolic syndrome treatment.
