Reasearch progress on the role of neutrophils in asthma
10.3785/j.issn.1008-9292.2016.09.15
- VernacularTitle:中性粒细胞在哮喘中作用的研究进展
- Author:
Tingting LI
1
;
Yuehai KE
;
Hongqiang CHENG
Author Information
1. 浙江大学医学院病理学与病理生理学系
- Keywords:
Asthma/physiopathology;
Neutrophils/physiology;
Helper T cell;
Review
- From:
Journal of Zhejiang University. Medical sciences
2016;45(5):543-548
- CountryChina
- Language:Chinese
-
Abstract:
Asthma is a phenotypically heterogeneous chronic disease of the airways . Studies have found that neutrophils are crucial to airway inflammation in acute asthma , persistent asthma , particularly in asthma of poor response to glucocorticoid treatment . The role of neutrophils in development of bronchial asthma is complex , as they can release a potent source of cytokines and inflammatory mediators participating in asthma . Differing from eosinophilic inflammatory asthma , neutrophilic inflammatory asthma is not depend on helper T ( Th)2 cells, but may be related to Th1 and Th17 cells.This review highlights the role of neutrophils in the development of asthma , and the treatment of neutrophilic asthma with biological agents and novel small molecules .
