Effectiveness of bupropion and counseling for smoking cessation
10.3760/cma.j.issn.0253-9624.2016.07.015
- VernacularTitle:盐酸安非他酮联合心理干预的戒烟效果评价
- Author:
Bin JIANG
1
;
Yao HE
;
Fang ZUO
;
Lei WU
;
Qinghui LIU
;
Li ZHANG
;
Changxi ZHOU
;
KK CHENG
;
Sophia SC CHAN
;
Taihing LAM
Author Information
1. 解放军总医院南楼中医针灸科
- Keywords:
Smoking cessation;
Bupropion;
Counselling
- From:
Chinese Journal of Preventive Medicine
2016;50(7):640-644
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effectiveness of bupropion for smoking cessation among Chinese smokers at a smoking cessation clinic. Methods A prospective observational study was conducted in a hospital located in Beijing during 2008 and from 28 to 31 October 2014. A total of 287 smokers (265 men and 22 women) were assessed using data from structured questionnaires at baseline and were followed up at 1 and 6 months. Trained physician counselors provided free brief education and individual counseling sessions for all participants at the first visit. A total 131 participants were prescribed bupropion in addition to counseling. The counseling plus bupropion group was compared with the group who underwent counseling without bupropion. Outcomes were self-reported 7-day point prevalence abstinence rates at 1-and 6-month follow-up and continuous abstinence rates at 6-month follow-up. Smoking reduction rates at 1 and 6 months were also measured. Results By intention-to-treat analysis, the 7-day point prevalence abstinence rate of the bupropion group at 1 and 6 months was higher than for the counseling-only group:at 1-month follow-up, 26.0% (34/131) vs. 15.4% (24/156), with OR (95%CI) 1.93(1.07-3.46); these rates at 6-month follow-up were 27.8% (35/131) vs. 15.4% (24/156), with OR (95%CI) 2.01(1.12-3.59). The 1-month continuous abstinence rate at 6 months was higher in the bupropion group: 26.0% (34/131) vs. 14.7% (23/156), with OR (95%CI) 2.03(1.12-3.66). Participants in the bupropion group also had a higher smoking reduction rate at 1 month than those in the counseling-only group:55.0%(72/131) vs. 38.5%(60/156), with OR (95%CI) 1.95 (1.22-3.13). Conclusion Prescription of bupropion at this smoking cessation clinic was effective in doubling the quitting rates and smoking reduction rates among Chinese smokers.
