Research progress on DNMT3A gene expression in Acute myeloid leukemia

VernacularTitle:急性髓系白血病中 DNMT3A基因表达的研究进展
Author: Jiawei ZHOU ¹ ; Tao WU ; Wenhui LIU
Author Information

1. 中国人民解放军联勤保障部队第九四〇医院，兰州　730050
Keywords: DNA methylation; DNMT3A gene; Acute myeloid leukemia
From: Chinese Journal of Medical Genetics 2024;41(8):1010-1015
CountryChina
Language:Chinese
Abstract: DNA methylation is an important epigenetic regulatory mechanism which plays a crucial role in cell differentiation and development. Its function is closely related to DNA methyltransferase 3 alpha (DNMT3A), which can affect gene expression and stem cell differentiation. The mutation rate of the DNMT3A gene is relatively high in Acute myeloid leukemia (AML), but its type and pathogenic mechanism are not yet clear. Further research on DNMT3A may help to identify its pathogenic targets and provide a basis for precise treatment of AML. This article has provided a review for the research progress on the expression of the DNMT3A gene in AML.