Research progress of piRNA as a biomarker for male infertility
10.3760/cma.j.cn511374-20230314-00132
- VernacularTitle:piRNA作为男性不育生物标志物的研究进展
- Author:
Hongying CHEN
1
;
Ruixue WANG
Author Information
1. 吉林大学第一医院生殖医学中心·产前诊断中心，长春 130021
- Keywords:
sncRNA;
PIWI /piRNA complex;
Male infertility;
Seminal plasma;
Exosome;
Spermatogenesis
- From:
Chinese Journal of Medical Genetics
2024;41(4):500-505
- CountryChina
- Language:Chinese
-
Abstract:
piRNA is a class of small non-coding RNA which specifically binds with PIWI protein. It is mainly expressed in germ cells and involved in the regulation of spermatogenesis. The role of piRNA pathway in the regulation of spermatogenesis mainly includes inhibition of transposons, induction of mRNA translation or degradation, and mediation of degradation of Miwi ubiquitination in late-stage sperm cells. With the detection of piRNA in seminal plasma, more attention has been attracted to whether piRNA can be used as a non-invasive molecular biomarker for the evaluation of spermatogenesis. This paper has reviewed recent studies on the mechanism of piRNA pathways mediating spermatogenesis and potential roles of piRNA disorders in the diagnosis and treatment of male infertility.
