A Case of Adrenocortical Carcinoma Secreting Cortisol, Androgen and Aldosterone.
10.3803/EnM.2011.26.3.239
- Author:
Jae Ho CHOI
1
;
Ye Ri SO
;
Yu Chul HWANG
;
In Kyung JEONG
;
Kyu Jeung AHN
;
Ho Yeon CHUNG
;
Seung Ae YANG
Author Information
1. Department of Internal Medicine, College of Medicine, Kyung Hee University, Seoul, Korea. chy1009@hotmail.com
- Publication Type:Case Report
- Keywords:
Adrenocortical carcinoma;
Androgen;
Cortisol;
Cushing's syndrome;
Primary aldosteronism
- MeSH:
Adrenalectomy;
Adrenocortical Carcinoma;
Aged;
Aldosterone;
Alkalosis;
Cushing Syndrome;
Female;
Humans;
Hydrocortisone;
Hypokalemia;
Mitotane;
Obesity, Abdominal
- From:Endocrinology and Metabolism
2011;26(3):239-242
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Primary adrenocortical carcinoma is a rare tumor, and is characterized by a peri-tumor mass effect and hormone excess signs. Adrenocortical carcinoma most commonly secretes cortisol, but tumors that secrete other adrenal hormones (aldosterone, androgen) are rare. Herein, we report the case of a 70-year-old woman with cortisol, androgen, and aldosterone-secreting adrenal carcinoma. The patient complained of generalized weakness, moon face, and central obesity. On laboratory examination, hypokalemia and metabolic alkalosis was detected. On the hormone test, cortisol, DHEA-S, and aldosterone were all increased. Abdominal CT showed a large right adrenal mass. She underwent right adrenalectomy and the histology revealed the presence of an adrenocortical carcinoma. After adrenalectomy, the patient was treated with hydrocortisone and mitotane.
