Research progress of mesenchymal stem cell-derived exosomes in hair regeneration

VernacularTitle:间充质干细胞来源外泌体在毛发再生中的研究进展
Author: Wanjun ZHANG ¹ ; Peihua ZHANG
Author Information

1. 广东医科大学附属医院整形外科，湛江　524000
Keywords: Mesenchymal stem cells; Exosome; Dermal papilla cells; Hair follicles
From: Chinese Journal of Plastic Surgery 2023;39(4):489-494
CountryChina
Language:Chinese
Abstract: Mesenchymal stem cells (MSCs) are a class of adult stem cells derived from mesoderm, which have the ability of self-renewal and multidirectional differentiation. Mesenchymal stem cells-derived exosomes(MSCs-Exo) are bioactive extracellular vesicles secreted by various MSCs into body fluids, which have the advantages of anti-inflammatory, repair, promoting tissue proliferation and differentiation,and regulating the hair growth cycle. Hair regeneration involves the interaction of various cells and cytokines. Dermal Papilla cells (DPCs) are considered as a unique MSCs with the functional properties of autologous stem cells. As the signal center of hair follicle, it plays an important role in regulating hair growth. MSCs-Exo can promote the proliferation and differentiation of DPCs by regulating the hair growth cycle. In recent years, the research of MSCs-Exo has provided a new strategy for hair regeneration. This article reviews the research of MSCs-Exo on hair regeneration, in order to provide new ideas for the treatment of alopecia.