Diagnostics and treatment challenges and research progress in early-onset gastric cancer
10.3760/cma.j.cn441530-20240125-00043
- VernacularTitle:早发性胃癌临床诊治难点与研究进展
- Author:
Shuo LI
1
;
Kecheng ZHANG
;
Lin CHEN
Author Information
1. 解放军总医院第一医学中心胃部外科，北京 100853
- Keywords:
Stomach neoplasms, early-onset;
Diagnostics;
Treatment;
Clinical characteristics;
Molecular characteristics
- From:
Chinese Journal of Gastrointestinal Surgery
2024;27(5):436-440
- CountryChina
- Language:Chinese
-
Abstract:
The incidence of gastric cancer has decreased, while the occurrence of early-onset gastric cancer has increased. There is no consensus on the definition of early-onset gastric cancer currently. The characteristics of tumor staging and differentiation, coupled with the lack of targeted comprehensive treatment, present a significant clinical challenge in managing early-onset gastric cancer. Relevant studies have analyzed the genetic characteristics of early-onset gastric cancer and have preliminarily revealed its relationship with Helicobacter pylori infection and molecular subtypes. These findings have the potential to contribute to the prevention and personalized treatment of early-onset gastric cancer. In the future, larger-scale evidence-based data are needed to establish diagnostic criteria, elucidate the mechanisms, and develop targeted diagnostic and therapeutic strategies of early-onset gastric cancer.
