Advances in studies on fetal wound scarless healing

VernacularTitle:胎儿伤口无瘢痕愈合的研究进展
Author: Yuan ZHOU ¹ ; Jian LEI ; Jie ZHANG ; Zelian QIN
Author Information

1. 北京大学第三医院成形外科，北京　100191
Keywords: Wound healing; Scar; Fetus; Fibroblast; Mesenchymal stem cell; Exosome
From: Chinese Journal of Plastic Surgery 2022;38(9):1037-1043
CountryChina
Language:Chinese
Abstract: Regeneration and repair are two different forms of human skin wound healing. Adult wounds can form scars through fibrous repair, while fetal skin wounds heal well without scars, and can even regenerate, completely restoring the structure and function of the original tissue. Understanding the different mechanisms of fetal wound healing is essential for developing new scar prevention therapies. In this review, the author summarized the recent research progress in scarless healing of fetal wounds, especially new discoveries in skin cells such as fibroblasts, mesenchymal stem cells and their exosomes and gene expression, immune cells and inflammation. It will be beneficial to develop new method to promote the development of adult wounds to scarless healing, and to provide new ideas for scar treatment and skin regeneration and repair by learning from the mechanism of fetal wound healing.