Research progress of microfluidic chip technology in sperm optimization
10.12025/j.issn.1008-6358.2023.20220768
- VernacularTitle:微流控芯片技术在精子优选中的研究进展
- Author:
Xin-Mei LU
1
;
Xi DONG
;
Su-Ying LIU
;
Hui-Juan SHI
Author Information
1. 复旦大学附属中山医院生殖医学中心,上海 200032;上海市生物医药技术研究院,国家卫生健康委员会计划生育药具重点实验室,上海 200237;复旦大学药学院,上海 200032
- Keywords:
microfluidic chip;
sperm quality;
sperm optimization;
DNA fragmentation;
in vitro fertilization
- From:
Chinese Journal of Clinical Medicine
2023;30(6):1061-1066
- CountryChina
- Language:Chinese
-
Abstract:
Sperm optimization is the key to in vitro fertilization(IVF)and is extremely important to improve the success rate of assisted reproductive technology(ART).Studies have confirmed that steps such as centrifugation in routine semen processing methods may lead to higher levels of reactive oxygen species(ROS)and damage sperm DNA.In the natural state,sperm needs to overcome a series of anatomical barriers in the female reproductive tract and migrates through"microchannels"formed by mucus.The microfluidic chip,characterized by miniaturization and automation,can simulate the process of natural selection in the female reproductive tract,and optimally obtain high-quality sperm from the original semen,which is important for improving IVF efficiency and improving pregnancy outcome.This review focuses on the recent advances in sperm optimization implemented in microfluidic chips and provides an outlook of its clinical application.
