Review of the research advances on the IL-33 / ILC2 axis in tissue regeneration and fibrosis
10.3760/cma.j.cn114453-20200608-00344
- VernacularTitle:IL-33/ILC2通路在组织损伤修复及纤维化中的作用机制研究进展
- Author:
Jieying TANG
1
;
Weiwei LI
;
Jianmin YANG
Author Information
1. 清华大学附属北京清华长庚医院整形外科 清华大学临床医学院，北京 102218
- Keywords:
Interleukin-33;
Fibrosis;
Keloid;
Group 2 innate lymphoid cell;
Pathogenesis
- From:
Chinese Journal of Plastic Surgery
2022;38(8):951-955
- CountryChina
- Language:Chinese
-
Abstract:
Persistent inflammation after tissue injury can lead to a chronic wounding status, which will result in tissue fibrosis and impaired function if not treated in time. In recent years, the role of innate immunity in tissue fibrosis has been emphasized. This review summarizes the central role of group 2 innate lymphoid cell(ILC2) in the innate immune system, which is participating in the immune reaction after stimulated by inflammation and infection. Il-33 /ILC2 pathway can be activated by a variety of inflammatory factors and produce type 2 immune cytokines after tissue injury, thus participating in the pathophysiological process of tissue repair and promoting the formation of fibrosis. The clinical correlation between IL-33/ILC2 pathway and typical skin fibrosis diseases (systemic sclerosis) is described, which provides a potential new target and theoretical basis for the drug treatment of other skin fibrosis (including keloid).
