Perioperative radiotherapy on local-advanced gastric cancer--From the perspective of failure pattern
10.3760/cma.j.cn441530-20221107-00455
- VernacularTitle:从复发模式看胃癌围手术期放疗的研究进展
- Author:
Longxiang GUO
1
;
Minghuan LI
Author Information
1. 山东第一医科大学（山东省医学科学院）山东省肿瘤防治研究院（山东省肿瘤医院）放疗科，济南 250117
- Keywords:
Stomach neoplasms;
Surgical treatment;
Radiotherapy;
Chemotherapy;
Recurrence pattern
- From:
Chinese Journal of Gastrointestinal Surgery
2023;26(8):807-811
- CountryChina
- Language:Chinese
-
Abstract:
Distant metastasis, peritoneal recurrence and locoregional recurrence are the three major patterns of gastric cancer (GC) recurrence after surgery and the causes of patients'death. Among them, distant organ metastasis or peritoneal recurrence after surgery is more common and occurs earlier, while locoregional failure alone occurs later with a relatively lower incidence. Several studies have confirmed that preoperative radiotherapy can shrink tumors and increase R0 resection rates, and postoperative radiotherapy helps reduce local recurrence. However, whether perioperative radiotherapy can further improve patient survival is still controversial.. We believe that this is partly due to the characteristics of recurrence and metastasis. As a local treatment, radiotherapy is complement to the inadequacy of surgery. Thus, we believe that perioperative radiotherapy is not recommended for patients with standard R0 surgery and adequate lymph node dissection, but rather requires accurate prediction of their recurrence and metastasis patterns based on accurate clinical and pathological staging, and thus screening of those who may benefit from radiotherapy.
