Research progresses of PI3K/Akt signaling pathway in hepatic ischemia-reperfusion injury
10.12025/j.issn.1008-6358.2018.20170926
- VernacularTitle:PI3K/Akt信号通路在肝脏缺血再灌注损伤中的研究进展
- Author:
Yong CHEN
1
;
Zhen FU
;
Lin FAN
;
Yan XIONG
;
Qi-Fa YE
;
Wei QIN
Author Information
1. 武汉大学中南医院
- Keywords:
PI3K/Akt;
ischemia-reperfusion injury;
inflammatory response;
oxidative stress;
apoptosis;
autophagy
- From:
Chinese Journal of Clinical Medicine
2018;25(1):103-107
- CountryChina
- Language:Chinese
-
Abstract:
Liver ischemia-reperfusion injury is the leading cause of delayed recovery of liver function and dysfunction after operation.Some studies have shown that PI3K/Akt signaling pathway is activated during ischemia and reperfusion,which plays a protective role on the liver by inhibiting or enhancing the expressions of downstream target proteins.Therefore,PI3K/ Akt signaling has become an important target pathway for preventing and improving hepatic ischemia-reperfusion injury.This review summarized the research progresses of PI3K/Akt signaling pathway in hepatic ischemia-reperfusion injury.
