Application of L *a *b * color mode in evaluation of the efficacy of topical timolol in the treatment of superficial infantile hemangioma
10.3760/cma.j.cn114453-20200402-00198
- VernacularTitle:L *a *b *色彩模式在外用噻吗洛尔治疗浅表型婴幼儿血管瘤效果评价中的应用
- Author:
Tingting JIN
1
;
Jingyu LI
;
Wei FENG
;
Yan CHEN
;
Qin WANG
;
Lei PAN
Author Information
1. 浙江省人民医院 杭州医学院附属人民医院整形外科 310014
- Keywords:
Timolol maleate drug combination;
Infantile hemangiomas;
Treatment outcome;
L *a *b *color mode
- From:
Chinese Journal of Plastic Surgery
2021;37(4):405-410
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the efficacy of 0.5% timolol maleate aqueous solution in the treatment of superficial infantile hemangioma (IH) and explore the feasibility of L *a *b * color system to assess the lesion color. Methods:A retrospective analysis was conducted on the data of superficial IH who received 0.5% timolol aqueous solution and met the inclusion criteria in the Department of Plastic Surgery of Zhejiang Provincial People’s Hospital from January 2014 to December 2018. Visual Analogue Scale (VAS) was used to evaluate the efficacy. Therapeutic responses were graded as follow: poor (VAS score ranging from -100 to 0), fair (VAS score ranging from 1-49), good (VAS score ranging from 50-89) and excellent (VAS score ranging from 90 to 100). The lesion color was expressed in terms of the Commission Internationale de l’Eclairage(CIE) L *a *b * color system, where L corresponds to the lightness, a to the red-green coordinate and b to the yellow-blue coordinate. Paired t-test was used to evaluate the difference of L value, a value and b value (ΔL, Δa and Δb) before and after treatment respectively. Pearson correlation analysis was carried out between ΔL, Δa and Δb with VAS score respectively. Results:A total of 25 cases (30 lesions) were reviewed, including 13 lesions on the head and neck, 9 in the trunk and 8 in the limbs. VAS evaluation showed that the overall response of fair was in 2 (6.7%) lesion, good in 8 (26.7%) lesion and excellent in 20 (66.7%) lesion. Percentage of excellent response in head and neck, trunk and limbs was 69.2%(9/13), 66.7%(6/9) and 62.5%(5/8) respectively, with no significant difference ( χ2=0.101, P=0.951). After treatment, L value increased by 9.25±8.96, a value decreased by 4.68±11.08, and b value decreased by 2.44±7.18 respectively, having statistical difference ( t=-8.383, P<0.001; t=3.763, P<0.001; t=2.813, P=0.006). ΔL value was positively correlated with VAS score ( r=0.616, P<0.001), while Δa value was negatively correlated with VAS score ( r=-0.640, P<0.001), and Δb value had no correlation with VAS score ( r=-0.028, P=0.883). Conclusions:0.5% timolol maleate aqueous solution is effective in the treatment of superficial IH. ΔL and Δa are highly correlated with VAS score, indicating that L *a *b * color system accurately reflects the chromatism of the lesion and could be provided as an objective index to evaluate the efficacy of superficial IH.
