Progress in the Study of Mechanisms Clinically Relevant to Insulin Resistance and Lung Cancer
10.3779/j.issn.1009-3419.2024.106.27
- VernacularTitle:胰岛素抵抗与肺癌临床相关机制的研究进展
- Author:
CHEN XIAOYU
1
;
CHEN PENG
Author Information
1. 300060 天津,天津医科大学肿瘤医院肺部肿瘤内科,国家恶性肿瘤临床医学研究中心,天津市恶性肿瘤临床医学研究中心,天津市肿瘤防治重点实验室
- Keywords:
Lung neoplasms;
Insulin resistance;
Insulin-like growth factor 1 receptor;
Drug resistance
- From:
Chinese Journal of Lung Cancer
2024;27(10):755-762
- CountryChina
- Language:Chinese
-
Abstract:
At present,the incidence and mortality rates of lung cancer rank top among malignant tumors.The early diagnosis,treatment and drug resistance of lung cancer still remain as problems in the management of lung cancer.Researchers are dedicated to identifying reliable biomarkers as predictive indicators or effective therapeutic targets for lung cancer.Insulin resistance(IR),a disorder characterized by reduced biological activity of insulin,leads to increased insulin secretion.In recent years,more and more studies have revealed the association between IR and the occurrence and development of cancer,with the insulin/insulin-like growth factor signaling pathway possibly playing a crucial role.In this article,we will focus on the rela-tionship between IR and lung cancer,explore the impact and mechanism of IR on the development,progression and drug resis-tance of lung cancer.It may guide the development of new predictive tools and therapeutic strategies,and provide new ideas for research dedicated to reducing the incidence and mortality of lung cancer.
