Research Progresses on the Effects of CCL4 on Immune Escape in Tumor Microenvironment
10.3779/j.issn.1009-3419.2024.106.23
- VernacularTitle:CCL4在肿瘤微环境中影响免疫逃逸的研究进展
- Author:
CHEN RAN
1
;
YANG XINYUE
;
LIU QIAN
;
ZHANG SHUCAI
;
MA LI
Author Information
1. 441000 襄阳,湖北医药学院附属襄阳市第一人民医院肿瘤科;101149 北京,首都医科大学附属北京胸科医院北京市结核病胸部肿瘤研究所肿瘤内科
- Keywords:
CCL4;
Immunotherapy;
Tumor microenvironment;
Immune response;
Immune escape
- From:
Chinese Journal of Lung Cancer
2024;27(8):613-621
- CountryChina
- Language:Chinese
-
Abstract:
Immunotherapy has become the cornerstone of current malignant tumor treatment.However,the response of different patients to immunotherapy is highly heterogeneous,and not all patients can benefit from it.There is an urgent need to find biomarkers that can effectively predict the efficacy of immunotherapy.C-C chemokine ligand 4(CCL4)is a cytokine,belonging to the inflammatory CCL subfamily.It is mainly secreted by immune cells and tumor cells and shows low or no expression in normal tissues but abnormally high expression in various malignant tumor tissues.After binding to CCL4 and its receptor C-C chemokine receptor type 5(CCR5),it can recruit and mediate immune cell migration,destroy the stabili-ty of the tumor microenvironment(TME),participate in carcinogenesis and promote the development of tumors.In the tumor immune microenvironment,CCL4 can mediate and recruit the directed migration of key immune cells such as monocytes,macrophages,natural killer(NK)cells,and T cells,which makes it a potentially important element affecting the efficacy of im-munotherapy and has specific value.This paper reviews the research progresses of CCL4's effects on immune escape in TME,in order to provide clues and references for basic research and clinical diagnosis and treatment.
