A Case of Adult B Lymphoblastic Leukemia with ider(9)(q10)t(9;22)(q34;q11.2) and der(19)t(1;19)(q23;p13.3).
10.3343/kjlm.2010.30.6.585
- Author:
Soon Il JUNG
1
;
Hee Soon CHO
;
Chae Hoon LEE
;
Bo Chan JUNG
Author Information
1. Department of Laboratory Medicine, Yeungnam University College of Medicine, Daegu, Korea. chscp@ynu.ac.kr
- Publication Type:Case Report ; Research Support, Non-U.S. Gov't
- Keywords:
Recurrent cytogenetic abnormalities;
B lymphoblastic leukemia;
ider(9)(q10)t(9;
22);
der(19)t(1;
19)
- MeSH:
Bone Marrow Cells/cytology/pathology;
Chromosome Deletion;
Chromosomes, Human, Pair 1;
Chromosomes, Human, Pair 19;
Chromosomes, Human, Pair 22;
Chromosomes, Human, Pair 9;
Female;
Fusion Proteins, bcr-abl/genetics/metabolism;
Humans;
In Situ Hybridization, Fluorescence;
Karyotyping;
Middle Aged;
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/*diagnosis/genetics;
*Translocation, Genetic
- From:The Korean Journal of Laboratory Medicine
2010;30(6):585-590
- CountryRepublic of Korea
- Language:English
-
Abstract:
In B lymphoblastic leukemia/lymphoma (B-ALL/LBL), t(9;22)(q34;q11.2) and t(1;19)(q23;p13.3) are recurrent cytogenetic abnormalities. The concurrent occurrence of both abnormalities is very rare, and only 3 cases have been previously reported. Here, we report a case of adult B-ALL with ider(9)(q10)t(9;22)(q34;q11.2) and der(19)t(1;19)(q23;p13.3). A literature review revealed that ider(9) (q10)t(9;22) is a rare variant of t(9;22) with a deletion of the short arm of chromosome 9. Fifteen cases of ider(9)(q10)t(9;22) have been reported. This abnormality is specific to precursor B-lymphoid neoplasms, such as B-ALL or B-lymphoid blast phase of CML, and is associated with disease progression or short survival. The cytogenetic abnormality t(1;19) is also specific to B-ALL. In most instances of t(1;19), TCF3 is fused to PBX1; however, a few cases have identical translocations but no TCF3-PBX1 fusion, as was observed in our patient. We describe the first case of ider(9)(q10)t(9;22) in combination with TCF3-PBX1 negative t(1;19). The patient underwent imatinib therapy in addition to intensive chemotherapy, but failed to achieve remission.
