Advances in Lung Stem Cells and Lung Cancer Stem Cells
10.3779/j.issn.1009-3419.2015.10.06
- VernacularTitle:肺干细胞和肺癌干细胞的研究进展
- Author:
YIN HUIJING
1
;
DENG JIONG
Author Information
1. 200025上海，上海交通大学医学院病理生理系，细胞分化与凋亡教育部重点实验室
- Keywords:
Lung stem cells;
Lung neoplasms;
Surface markers;
Signal pathway;
Targeted therapy
- From:
Chinese Journal of Lung Cancer
2015;(10):633-639
- CountryChina
- Language:Chinese
-
Abstract:
Cancer stem cells (CSCs) are emerging as a hot topic for cancer research. Lung CSCs share many char-acteristics with normal lung stem cells (SCs), including self-renewal and multi-potency for differentiation. Many molecular markers expressed in various types of CSCs were also found in lung CSCs, such as CD133, CD44, aldehyde dehydrogenase (ALDH) and ATP-binding cassette sub-family G member 2 (ABCG2). Similarly, proliferation and expansion of lung CSCs are regulated not only by signal transduction pathways functioning in normal lung SCs, such as Notch, Hedgehog and Wnt path-ways, but also by those acting in tumor cells, such as epidermal growth factor receptor (EGFR), signal transducer and activator of transcription 3 (STAT3) and phosphatidylinositol 3 kinase (PI3K) pathways. As CSC plays an critical role in tumor recur-rence, metastasis and drug-resistance, understanding the difference between lung CSCs and normal lung SCs, identifying and targeting CSC markers or related signaling pathways may increase the effcacy of therapy on lung cancer and improved survival of lung cancer patients.
