Neoadjuvant treatment for locally advanced gastric cancer
10.3760/cma.j.cn112152-20200521-00473
- VernacularTitle:局部进展期胃癌的新辅助治疗
- Author:
Lulu ZHAO
1
;
Dongbing ZHAO
;
Yingtai CHEN
Author Information
1. 国家癌症中心 国家肿瘤临床医学研究中心 中国医学科学院北京协和医学院肿瘤医院胰胃外科 100021
- Keywords:
Stomach neoplasms, locally advanced;
Neoadjuvant therapy;
Chemotherapy
- From:
Chinese Journal of Oncology
2020;42(11):907-911
- CountryChina
- Language:Chinese
-
Abstract:
Gastric cancer is the second most common and the second leading cause of cancer related mortality in China, which seriously endanger the lives and health of Chinese people. Due to the lack of typical symptoms and screening system of early gastric cancer, about 70% patients with gastric cancer are diagnosed as locally advanced disease in China. Radical resection is the main approach for locally advanced gastric cancer (LAGC), however, the clinical effect of gastrectomy alone or gastrectomy plus adjuvant treatment is limited. As a result, there has been increasing interest in the neoadjuvant treatment, which could potentially downstage tumor, eliminate tumor micrometastasis, reduce intraoperative dissemination and postoperative recurrence, thus improve the prognosis of patients with LAGC. The exploration and application of chemotherapy, radiotherapy, targeted therapy and immunotherapy of neoadjuvant treatment in LAGC have made continuous progress in recent years. To date, neoadjuvant therapy has been developed as a part of multimodality treatment for patients with LAGC.
