Values of serum Delta-like protein 4 and cAMP response element-binding protein levels in predicting microvascular injury of patients with different stages of diabetic retinopathy
- VernacularTitle:糖尿病视网膜病变不同分期患者血清δ样蛋白4和环磷腺苷效应元件结合蛋白水平对微血管损伤的预测价值
- Author:
Jing GUO
1
;
Yunyun LI
;
Sisi LIU
;
Ying SHA
;
Kai MA
;
Hong WANG
Author Information
- Keywords: diabetic retinopathy; Delta-like protein 4; cAMP response element-binding pro-tein; microvascular injury; endothelial progenitor cells; circulating endothelial cells; circulating progenitor cells
- From: Journal of Clinical Medicine in Practice 2023;27(23):68-72,78
- CountryChina
- Language:Chinese
- Abstract: Objective To analyze the values of serum Delta-like protein 4(DLL4)and cAMP response element-binding protein(CREB)levels in predicting microvascular injury of patients with different stages of diabetic retinopathy(DR).Methods Eighty diabetic patients from February 2020 to February 2023 were selected as research objects,and they were divided into no DR group(n=37),non-proliferative DR group(n=19)and proliferative DR group(n=24)according to different stages of DR;serum DLL4 and CREB levels in the blood were detected,and the FACS Count flow cytometry was used to detect levels of endothelial progenitor cells(EPC),circulating endothelial cells(CEC)and circulating progenitor cells(CPC)in patients.Results The levels of DLL4 and CREB in the blood of proliferative DR group were the highest,while the levels of DLL4 and CREB in the no DR group were the lowest,and the differences were statistically significant(P＜0.05);different stages of DR were significantly positively correlated with the levels of DLL4 and CREB(P＜0.05);the high levels of DLL4 and CREB in the blood of diabetic patients were the independent risk factors affecting staging of DR(P＜0.05).The levels of EPC and CPC in the blood of proliferative DR group were the lowest,while the level of CEC was the highest;in the no DR group,the levels of EPC and CPC were the highest,while the level of CEC was the lowest,and the differences were statistically signifi-cant(P＜0.05);the levels of DLL4 and CREB were significantly negatively correlated with EPC and CPC levels(P＜0.05),while the levels of DLL4 and CREB were significantly positively corre-lated with CEC level(P＜0.05);the area under the curve(AUC)of both DLL4 and CREB in pre-dicting microvascular injury in DR patients was greater than 0.85.Conclusion As the staging of DR increases,the levels of serum DLL4 and CREB show a significant upward trend,and DLL4 and CREB have higher predictive values for microvascular injury.
