Clinical outcomes and prognostic factors in limited-stage small cell lung cancer：a single institution experience
10.3760/cma.j.issn.0253-3766.2015.03.015
- VernacularTitle:局限期小细胞肺癌放化疗综合治疗的疗效和预后影响因素分析
- Author:
Wenjue ZHANG
1
;
Hui ZHU
;
Zongmei ZHOU
;
Qinfu FENG
;
Dongfu CHEN
;
Hongxing ZHANG
;
Zefen XIAO
;
Lühua WANG
Author Information
1. 100021,北京协和医学院 中国医学科学院肿瘤医院肿瘤研究所放疗科
- Keywords:
Carcinoma,small celll;
Treatment outcome;
Prognosis;
Limited stage;
Chemoradiotherapy
- From:
Chinese Journal of Oncology
2015;(3):223-226
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of comprehensive treatment and examine the impact of clinical factors on the survival outcome of limited-stage small cell lung cancer.Methods The clinical records of 335 patients with limited-stage small cell lung cancer treated in the Cancer Hospital of Chinese Academy of Medical Sciences between January 1996 and December 2006 were analyzed retrospectively in this study.Kaplan-Meier method was used for survival analysis, and log-rank test and Cox regression were used for univariate and multivariate analyses of prognostic factors.Results The median follow-up time was 54 months for all patients, the median survival time was 23.8 months, and progression-free survival was 12.5 months.The 2-,3-, and 5-year overall survival rates were 47.3%, 32.9%, and 22.9%, respectively. The acute toxicity during comprehensive treatment was tolerable.The incidence of ≥grade 3 hematological toxicity,≥grade 3 gastrointestinal toxicity,≥grade 2 radiation pneumonitis and≥grade 2 acute esophagitis were 37.0%, 14.9%, 11.0%, and 38.8%, respectively.The univariate analysis showed that KPS<80, smoking and high LDH level significantly reduced the overall survival time in patients with limited-stage SCLC.The multivariate analysis showed that KPS and weight loss were independent factors affecting the prognosis for the limited stage SCLC patients ( P <0.05 for all ). Conclusions Sequential chemoradiotherapy can be safely and effectively performed in limited-stage small cell lung cancer.Krnofsky performance status and weight loss are independent prognostic factors for the overall survival of LS-SCLC.
