Establishment of collection methods and laboratory testing methods for active pharmaceutical ingredient in the workplace air
10.3760/cma.j.cn121094-20230802-00270
- VernacularTitle:工作场所空气中活性药物成分现场采集和实验室检测方法的建立
- Author:
Xiaowei FANG
1
;
Zhonglin ZHAO
;
Jing ZHANG
;
Yuan SUN
;
Xiang WANG
Author Information
1. 上海市化工职业病防治院，上海 200041
- Keywords:
Workplace air;
Active pharmaceutical ingredient;
Collection;
Liquid chromatography-triple quadrupole mass spectrometer
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2024;42(6):457-462
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To establish collection methods and laboratory testing methods for qualitative and quantitative analysis of 9 typical active pharmaceutical ingredient in the workplace air.Methods:In December 2021, a mixed solution of nine analytes was prepared and then dispersed in aerosol state to simulate sampling. Glass fiber filter membrane was selected as air collector and collected active pharmaceutical ingredient in the air at a rate of 2.0 L/min for 15 minutes. Then, the obtained filter membrane samples were eluted with 25%ACN/75%MeOH. Finally, the eluent was qualitatively and quantitatively analyzed with liquid chromatography-triple quadrupole mass spectrometer.Results:This method could effectively collect active pharmaceutical ingredient in the air, with an average sampling efficiency of more than 98.5%. The linear correlation coefficient r was greater than 0.9990. The lower limit of quantification for each analyte ranged from 0.6~500.0 ng/ml, and the average recovery rate ranged from 97.6%~102.5%.Conclusion:This method could simultaneously collect 9 active pharmaceutical ingredient in the workplace air, and could provide accurate qualitative and quantitative analysis in subsequent laboratory tests.
