Study on Limonin Distribution in Rat Intestine by LC-MS/MS Method
10.14148/j.issn.1672-0482.2016.0379
- VernacularTitle:LC-MS/MS 研究柠檬苦素在大鼠肠道内的分布
- Author:
Nong-Shan ZHANG
1
;
Guo-Liang DAI
;
Li-Wen FENG
;
Chang-Yin LI
;
Guo-Dong HUANG
;
Ia Shi-j LIU
;
Wen-Zheng JU
Author Information
1. 南京中医药大学附属医院
- Keywords:
limonin;
intestine distribution;
LC-MS/MS;
tissue concentration;
pharmacokinetics
- From:
Journal of Nanjing University of Traditional Chinese Medicine
2016;32(4):379-382
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE Integral animal experiment was employed to investigate the limonin distribution in different parts of rats?? intestine.METHODS The concentration of limonin in different parts of the intestinal was detected by LC-MS/MS meth-od.After the rats were given the limonin 80 mg/kg ig,the drug concentrations in the duodenum,small intestine and rectum were detected at 2,3,4,6 and 8 h.RESULTS Limonin was highly distributed in different parts of the intestinal tissue.Most of intestinal tissue reached peak concentration at 3~4 h after administration.The drug concentration in the duodenum and rectum was the highest,with duodenum being the second.CONCLUSION Limonin has a wide distribution and high concentration in rat intestine,and it plays a direct role in the treatment of hemorrhoids in intestine.
