Determination of 14 volatile organic compounds in urine by headspace gas chromatography-mass spectrometry
10.3760/cma.j.cn121094-20220711-00365
- VernacularTitle:尿液中14种挥发性有机物测定的自动顶空气相色谱-质谱法
- Author:
Sanyan ZHENG
1
;
Meixuan FANG
;
Qifa MA
;
Xiaodong LI
;
Luoluo CHEN
Author Information
1. 温州市疾病预防控制中心理化所，温州 325000
- Keywords:
Gas chromatography-mass spectrometry;
Organic;
Urine
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2023;41(10):850-854
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To establish a automatic headspace gas chromatography-mass spectrometry (HS/GC-MS) method for the determination of 14 volatile organic compounds in urine.Methods:In September 2022, 10 ml urine sample was taken into a 20 ml headspace bottle, balanced for 30 min at 65 ℃, and then detected by HS/GC-MS and quantified by external standard method.Results:The 14 volatile organic compounds showed good linearity at 0.2-8.0 μg/L and 0.1-4.0 μg/L, with correlation coefficients ranging from 0.9956-0.9999. The recoveries were 79.8%-113.1% with relative standard deviations 0.05%-0.27% when three different concentration levels were added. Detection limit was 0.03-0.05 μg/L.Conclusion:The method is simple and convenient, and the recovery and precision meet the requirements. It can be used for the determination of common volatile organic compounds in urine.
