Influencing factors for postoperative survival of patients with pneumoconiosis treated by lung transplantation
10.3760/cma.j.cn121094-20210906-00441
- VernacularTitle:尘（矽）肺患者肺移植术后的生存分析
- Author:
Weixiang WANG
1
;
Yongchun CHEN
;
Tong QIAO
;
Wenping ZHANG
;
Wen WANG
;
Li WEI
Author Information
1. 河南省人民医院（郑州大学人民医院）临床营养科，郑州 450003
- Keywords:
Pneumoconiosis;
Lung transplantation;
Risk factors;
Survival rates
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2022;40(12):907-910
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the influencing factors for postoperative survival of patients with pneumoconiosis (silicosis) after lung transplantation in order to improve their clinical outcomes.Methods:In August 2021, retrospective alalysis from December 2015 to July 2021, 29 patients with end-stage pneumoconiosis underwent lung transplantation at Department of Thoracic Surgery, Affiliated Henan Provincial People's Hospital, Zhengzhou University. The survival, postoperative complications, and causes of death were analyzed. Life table and Kaplan-Meier method were used to draw survival curves, the log-rank test was used to compare the influence of each factor on survival rates, and the multivariate Cox proportional hazards regression model was used to evaluate the influence of each factor on survival.Results:All the patients underwent successful lung transplantation, with survival rates of 75% at 6 months, 70% at 1 year, 65% at 2 years, 50% at 3 years and 50% at 5 years. The Kaplan-Meier survival analysis showed that BMI, age and preoperative albumin level were influencing factors for postoperative survival rates ( P<0.05) . The multivariate COX regression model showed that BMI≥18.5 kg/m 2 and the albumin level≥35 g/L were the protective factors ( P<0.05) . Conclusion:Aging older, preoperative BMI<18.5 kg/m 2 and hypoalbuminemia are independent risk factors for death after lung transplantation. Survival rates are affected by preoperative BMI index, albumin level and age. Early intervention should be made before lung transplantation to promote the BMI index and albumin level to reach the standard.
