Effect of atypical antipsychotics on glial cell line-derived neurotrophic factor levels in schizophrenia patients
10.7619/jcmp.201721003
- VernacularTitle:非典型抗精神病药物对精神分裂症患者血清胶质源性神经营养因子水平的影响
- Author:
Xinming PAN
1
;
Xuefeng HU
;
Lu WEN
;
Xiuxiu HU
;
Xiaobin ZHANG
Author Information
1. 江苏省南京市江宁区第二人民医院
- Keywords:
schizophrenia;
glial cell line-derived neurotrophic factor;
antipsychotics
- From:
Journal of Clinical Medicine in Practice
2017;21(21):12-14,18
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study effect of atypical antipsychotics on glial cell line-derived neurotrophic factor (GDNF) levels in schizophrenia patients.Methods A total of 104 drug-free schizophrenic patients and 70 healthy controls were recruited.All patients were treated with atypical antipsychotic monotherapy.GDNF serumlevels and psychiatric symptoms were assessed at baseline and at 2,4,6 and 8 weeks of treatment.Results Baseline serum GDNF levels were significantly lower in schizophrenic patients than healthy controls (t =5.596,P ＜ 0.001).GDNF levels gradually increased accompanied by a reduction in psychiatric symptoms during antipsychotic therapy (P ＜ 0.01).The levels of GDNF in responders were significantly changed after treatment (P ＜ 0.01),however,no significant change was found in non-responders (P ＞ 0.05).Furthermore,a negative association between GDNF levels after pharmacotherapy and disease duration in schizophrenic subjects could be observed (r =-0.270,P =0.024).Conclusion The present study suggests that GDNF may be involved in the mechanisms of schizophrenia pathogenesis and pharmacological efficacy.
