The role of epigenetic effect in the trichloroethylene toxicity
10.3760/cma.j.cn121094-20200602-00313
- VernacularTitle:三氯乙烯表观遗传效应在其毒性中的作用
- Author:
Hua HUANG
1
;
Jiaxiang ZHANG
;
Qixing ZHU
Author Information
1. 230032 合肥，安徽医科大学公共卫生学院职业卫生与环境卫生学系
- Keywords:
Trichloroethylene;
Genetic;
Genetic epigenetic;
Toxic actions;
DNA methylation;
Histone modification;
MicroRNA
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2021;39(5):385-389
- CountryChina
- Language:Chinese
-
Abstract:
Trichloroethylene (TCE) is a commonly used organic solvent in industry and it was classified as a Group I carcinogen by IARC, with immunotoxicity, hepatotoxicity, kidney toxicity and neurotoxicity. Increasing evidence suggests that TCE-induced autoimmune diseases and cancer are involved in epigenetic modifications. This paper summarized the mechanism of DNA methylation, histone modification and microRNA in toxicity of TCE according to the newly published articles, so as to provide new ideas for further revealing the mechanism of TCE exposure affecting health.
