Analysis of related risk factors in the occurrence of mercury-toxic nephrotic syndrome
10.3760/cma.j.cn121094-20200326-00156
- VernacularTitle:汞中毒性肾病综合征发病的相关因素分析
- Author:
Bin ZHOU
1
;
Shengping LIU
;
Junsheng ZHOU
;
Yuguo SONG
Author Information
1. 230022 合肥，安徽医科大学合肥第三临床学院（合肥市第三人民医院）
- Keywords:
Mercury poisoning;
Nephrotic syndrome;
Risk factors;
Absorption pathway
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2021;39(4):289-292
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyse the clinical characteristics of mercury-toxic nephrotic syndrome and to find the risk factors.Methods:A total of 126 patients with mercury-toxic admitted to Beijing Chaoyang Hospital from January 2017 to January 2020 were selected as the research objectives. General data such as age, gender, mercury exposure history of all patients and laboratory data such as urine mercury and urine creatinine were collected. The clinical manifestations and pathological types of patients with mercury-toxic nephrotic syndrome were analyzed, and the risk factors of mercury-toxic nephrotic syndrome were found by univariate and multivariate logistic regression analysis.Results:Among the 24 patients with mercury-toxic nephrotic syndrome, 1 was poisoned by respiratory tract, 6 were poisoned by digestive tract, and 17 were poisoned by skin absorption. In addition to the manifestations of kidney injury, some of the patients also showed neurological symptoms such as dizziness, fatigue, hand tremor, and limb pain. The main pathological types were membranous nephropathy (9 cases) and micropathological nephropathy (10 cases) . The results of multivariate logistic regression analysis showed that the digestive tract and skin absorption pathways of mercury were risk factors for mercury-toxic nephrotic syndrome ( OR=21.099, 23.840, P<0.05) . Conclusion:The absorption pathway of mercury has an important influence on the pathogenesis of mercury-toxic nephrotic syndrome, especially in patients with mercury poisoning absorbed by the skin and digestive tract, the risk of complicating nephrotic syndrome is higher.
