Furazolidone combined with omeprazole and levofloxacin versus tinidazole combined with omeprazole and levofloxacin in eradication rate of helicobacter pylori in elderly patients with Hp positive chronic atrophic gastritis
10.7619/jcmp.201713009
- VernacularTitle:呋喃唑酮与替硝唑分别联合奥美拉唑、左氧氟沙星三联对老年Hp阳性慢性萎缩性胃炎幽门螺旋杆菌根除率的比较研究
- Author:
Yumei WU
1
;
Jichang LI
;
Haixia LIU
Author Information
1. 陕西省宝鸡市中心医院 消化科
- Keywords:
furazolidone;
elderly;
Hp positive chronic atrophic gastritis;
eradication rate of helicobacter pylori
- From:
Journal of Clinical Medicine in Practice
2017;21(13):32-35,44
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the eradication rate of helicobacter pylori between furazolidone combined with omeprazole and levofloxacin and tinidazole combined with omeprazole and levofloxacin in elderly patients with Hp positive chronic atrophic gastritis.Methods A total of 96 patients with Hp positive chronic atrophic gastritis were randomly divided into two groups,48 cases in each group.Control group was treated with tinidazole plus omeprazole and levofloxacin,while study group was treated with furazolidone plus with omeprazole and levofloxacin.The gastric function,inflammatory factors and immune function indexes were measured,and the clinical efficacy and the eradication rate of Hp were compared.Results After treatment,symptoms and pathological scores significantly decreased in both groups,G-17,PG-I contents increased significantly,PG-II content decreased significantly,serum IL-6,TNF-α,sIL-2R contents decreased significantly,CD4+ and CD4+/CD8+ contents increased significantly,and CD8+ content decreased significantly(P<0.05).There were significant differences in indexes mentioned above between the two groups(P<0.05).The effective rate and negative rate of Hp in the control group were significantly lower than those in the study group(P<0.05).Conclusion Furazolidone combined with omeprazole and levofloxacin
