Association between GPX1 gene polymorphisms and noise-induced hearing loss
10.3760/cma.j.issn.1001-9391.2020.02.008
- VernacularTitle:GPX1基因多态性与噪声性听力损失易感性的关系
- Author:
Jingyun LI
1
;
Jie JIAO
;
Guoshun CHEN
;
Guizhen GU
;
Huanling ZHANG
;
Shanfa YU
Author Information
1. 102308 北京，国家卫生健康委职业安全卫生研究中心
- Keywords:
Hearing loss, Noise;
GPX1 gene;
Noise-Induced hearing loss;
Single nucleotide polymorphism;
SNP;
Genetic variability
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2020;38(2):116-120
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To identify association between genetic polymorphism in the Glutathione peroxidase 1 gene (GPX1) and noise-induced hearing loss (NIHL) .Methods:A nested case control study was conducted based on a cohort of noise-exposed subjects. 392 cases were selected from the steel factory in Henan Province, 392 matched control subjects for each case were designated on the basis of the matched criterion including same gender, age (±5years) and duration of exposure to noise (±2years) . Two single nucleotide polymorphisms (SNPs) of GPX1 were genotyped by SNPscanTM multiplex SNP genotyping kit. Hardy-Weinberg equilibrium (HWE) tests were performed using Pearson's χ 2 for each SNP among control group, effects of genotypes of GPX1 on NIHL were analyzed by logistic regression. Results:All two SNPs were in HWE. After adjustment for covariates including smoking status, rs1987628 polymorphism was statistically significantly associated with the NIHL risk under codominant and Dominant inheritance models; In the subjects carrying rs1987628 GA genotype had a higher NIHL risk than those carrying the GG genotype, the adjusted OR value was 1.803 (95% CI 1.215-2.676, P=0.003) . And meanwhile, rs1987628 GA+AA genotype had a higher NIHL risk than those carrying the GG genotype, the adjusted OR value was 1.762 (95% CI 1.197-2.593, P=0.004) . Conclusion:It was suggested that genetic polymorphism in the GPX1 gene might be the genetic susceptible factor for NIHL.
