Programmed death ligand 1 negatively regulates inflammatory response of chronic periodontitis
- VernacularTitle:程序性死亡配体1负性调控慢性牙周炎的炎症反应
- Author:
Wenwen YUAN
1
;
Xiaoqian WANG
;
Jiehua ZHANG
;
Wenjie ZHOU
;
Yun FENG
;
Jiao CHEN
;
Ping ZHANG
Author Information
- Keywords: programmed death ligand 1; chronic periodontitis; immunoregulation; alveolar absorption
- From: West China Journal of Stomatology 2015;(4):366-369
- CountryChina
- Language:Chinese
- Abstract: Objective??To?investigate?whether?programmed?death?ligand?1?(PD-L1)?expressed?in?the?periodontal?tissue?of?chronic?periodontitis?and?the?correlativity?of?PD-L1?and?different?degrees?of?chronic?periodontitis,?provide?experience?for?immunoregulation?mechanism,?clinical?treatment?and?prognosis?of?chronic?periodontitis. Methods??Gingiva?and?periodontal?tissue?of?healthy?people?and?chronic?periodontitis?patients?were?collected.?Based?on?clinical?probing,?periodontal?tissue?were?classified?into?three?groups:?periodontal?tissues?of?healthy?people,?periodontal?tissue?of?mild?chronic?periodontitis,?periodontal?tissue?of?severe?chronic?periodontitis.?Fluorescent?quantitation?polymerase?chain?reaction?was?applied?to?explore?the?expression?of?PD-L1?mRNA?in?the?periodontal?tissue?of?the?different?groups.?Western?blot?and?immunohistochemistry?method?were?utilized?to?test?the?expression?of?PD-L1?protein?in?the?periodontal?tissue?of?the?different?groups.?Combining?with?clinical?image?data,?the?relationship?between?differentially?expressions?of?PD-L1?and?different?degrees?of?chronic?periodontitis?was?analyzed.?Results??The?relative?expression?quantity?of?PD-L1?in?the?periodontal?tissue?of?the?mild?chronic?periodontitis?was?significantly?higher?that?of?the?severe?chronic?periodontitis?(P<0.01).?The?relative?expression?quantity?of?PD-L1?in?the?periodontal?tissue?of?healthy?subjects?and?severe?chronic?periodontitis?had?no?statistical?significance?(P>0.05).?Conclusion??The?expression?of?PD-L1?in?the?periodontal?tissue?negatively?regulates?inflammatory?periodontal?tissue?damage.
