Clinical significance of combined detection of CA19-9,CA125,CA242 and CEA levels in patients with pancreatic cancer
10.7619/jcmp.201416009
- VernacularTitle:胰腺癌患者联合检测 CA19-9、CA125、CA242、CEA 的临床意义
- Author:
Tuersun ALIJAN
1
;
Yuefen ZHANG
;
Yongxing BAO
Author Information
1. 新疆医科大学第一附属医院 肿瘤中心
- Keywords:
pancreatic cancer;
tumor marker;
carbohydrate antigen 19-9;
carcinoembry-onic antigen;
carbohydrate antigen 125;
carbohydrate antigen 242;
pancreatitis
- From:
Journal of Clinical Medicine in Practice
2014;(16):33-35
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical significance of combined detection of serum carbohydrate antigen 19-9 (CA-19-9),carcinoembryonic antigen (CEA),carbohydrate antigen 125 (CA125)and carbohydrate antigen 242 (CA242)in patients with pancreatic cancer.Methods 65 patients with pancreatic cancer were designed as pancreatic cancer group,another 64 patients with benign pancreatic disease and 66 healthy people with physical examinations at the same period were designed as benign pancreatic disease group and control group respectively.Serum CA19-9,CEA, CA125 and CA242 levels were observed among 3 groups,and the single and combined detection of the sensitivity and specificity of above 4 diagnostic indexes in detecting pancreatic cancer were con-ducted.Results Serum CA19-9,CEA,CA125 and CA242 levels were significantly higher in pan-creatic cancer group than the other two groups (P <0.01),and the sensitivity and specificity of combined detection of above 4 indexes were 87.69% and 91.54% respectively.Conclusion Serum CA19-9,CEA,CA125 and CA242 levels increase significantly in patients with pancreatic cancer, and their combined detection has a higher diagnostic value.
