Association of single nucleotide polymorphisms in the promoter of GABAA receptor β2 subunit gene with schizophrenia
10.3969/j.issn.1673-4254.2015.02.20
- VernacularTitle:GABRB2基因启动子区单核苷酸多态性与精神分裂症的关联
- Author:
Lin ZHOU
1
;
Lu ZONG
;
Lulu ZHANG
;
Cong DENG
;
Cunyou ZHAO
Author Information
1. 南方医科大学基础医学院遗传学教研室
- Keywords:
schizophrenia;
GABRB2 gene;
promoter;
single nucleotide polymorphism
- From:
Journal of Southern Medical University
2015;(2):256-259
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the genetic association between schizophrenia and the polymorphism of GABAA receptorβ2 subunit (GABRB2) gene. Methods A population association analysis was performed of 5 single nucleotide polymorphisms (SNPs) in the proximal promoter of GABRB2 gene by PCR and sequencing of the genomic DNA in a cohort of 172 schizophrenics and 167 controls of Chinese Han nationality. Results One out of the 5 SNPs, namely rs3811996, was found to be significantly associated with schizophrenia especially in the male cohorts, where the heterozygous genotypes (A/G) and minor allele G displayed lower frequencies in case group than in the controls. Conclusion We found a new risk, SNP rs3811996, for paranoia schizophrenia, which further supports the importance of genetic variations of GABRB2 in the etiology of schizophrenia.
