Overweight/obese status associates with favorable outcome in patients with metastatic nasopharyngeal carcinoma:a 10-year retrospective study
10.1186/s40880-016-0139-6
- Author:
Li WANG
1
;
Shen LUJUN
;
Chen TAO
;
Sun XUQI
;
Zhang YING
;
Wu MING
;
Shu WANHONG
;
Chen CHEN
;
Pan CHANGCHUAN
;
Xia YUNFEI
;
Wu PEIHONG
Author Information
1. State Key Laboratory of 0ncology in South China
- Keywords:
Nasopharyngeal carcinoma;
Body mass index;
Metastasis;
Prognosis
- From:Chinese Journal of Cancer
2016;35(9):476-484
- CountryChina
- Language:Chinese
-
Abstract:
Background: Although the prognostic impact of body mass index (BMI) in patients with non?metastatic naso?pharyngeal carcinoma (NPC) had been extensively studied, its effect among metastatic NPC patients remains unknown. The purpose of this study was to evaluate the prognostic effect of BMI in patients with metastatic NPC. Methods: We retrospectively studied 819 patients who were diagnosed with distant metastasis from NPC and received treatment between 1998 and 2007. The patients were divided into three subgroups according to the World Health Organization classifications for Asian populations: underweight (BMI <18.5 kg/m2), normal weight (BMI 18.5–22.9 kg/m2), and overweight/obese (BMI ≥23.0 kg/m2). The associations of BMI with overall survival (OS) andprogression?free survival (PFS) were determined by Cox regression analysis. Results: Of the 819 patients, 168 (20.5%) were underweight, 431 (52.6%) were normal weight, and 220 (26.9%) were overweight/obese. Multivariate analysis adjusted for covariates showed that overweight/obese patients had a longer OS than underweight patients [hazard ratio (HR), 0.64; 95% confidence interval (CI), 0.49–0.84] and normal weight patients (HR, 0.72; 95% CI, 0.57–0.90); no significant difference in PFS was observed among these three groups (P = 0.407). Moreover, in stratified analysis, no statistically significant differences in the effect of overweight/obesestatus among different subgroups were observed. Conclusion: For patients with metastatic NPC, overweight/obese status was associated with longer OS but not longer PFS compared with underweight or normal weight status.
