Peripheral arterial thromboembolism in patients with non valvular atrial fibrillation:a single center case-control study
10.3760/cma.j.issn.0253-3758.2014.07.011
- VernacularTitle:非瓣膜病心房颤动患者发生外周动脉栓塞的单中心病例对照研究
- Author:
Sanshuai CHANG
1
;
Dong CHANG
;
Jie QIU
;
Qiaobing SUN
;
Shulong ZHANG
;
Yunlong XIA
;
Yanzong YANG
;
Lianjun GAO
Author Information
1. 116011,大连医科大学附属第一医院心内科
- Keywords:
Atrial fibrillation;
Thromboembolism;
Intracranial embolism;
Risk factors
- From:
Chinese Journal of Cardiology
2014;(7):577-581
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical characteristics and risk factors of peripheral arterial thromboembolism (PAT) in patients with non valvular atrial fibrillation (NVAF).Methods A total of 18 456 patients admitted in our hospital and diagnosed with NVAF were included in this study.The study population was divided into three groups [ PAT group, cerebral thromboembolism ( CT ) group and no thromboembolism group ].Risk factors of PAT were assessed by multivariate logistic regression.Results The incidence of PAT and CT was 1.1%( 204 cases ) and 27.8%( 5 132 cases ) , respectively.The in-hospital mortality of PAT group was 11.8%(24/204), in which the in-hospital mortality due to mesenteric arterial thromboembolism ( 37.5%, 6/16 ) was the highest.Multivariate logistic regression indicated that vascular disease(OR=3.9,95%CI 2.13-7.08, P<0.01), age≥65 years(OR=2.7, 95%CI 1.66-4.27,P<0.01), hypertension(OR=2.1, 95%CI 1.36-3.34,P<0.01), history of stroke/TIA/arterial thromboembolism(OR=2.0,95%CI 1.26-3.17,P<0.01) and congestive heart failure(OR=1.9,95%CI 1.22-2.86,P<0.01) were independent risk factors of PAT.Prevalence of vascular disease and histories of PAT was higher in PAT group than in CT group (P<0.01), while CHADS2 and CHA2DS2VASc scores were similar between the PAT and CT groups.Conclusion PAT is not uncommon in NVAF patients , risk factors for PAT in NVAF patients are vascular disease , advanced age , hypertension , history of stroke/TIA/arterial thromboembolism and congestive heart failure .
