Intraoperative methylene blue and 99mTc-sulfur colloid isotope tracing for sentinel node mapping in early-stage non-small cell lung cancer
10.3969/j.issn.1673-4254.2014.07.28
- VernacularTitle:联合亚甲蓝和99mTc-硫胶体核素示踪法在早期非小细胞肺癌前哨淋巴结定位中的应用
- Author:
Bin HONG
1
;
Xueyuan SHEN
;
Jiangyong CHEN
Author Information
1. 重庆医科大学附属永川医院心胸外科
- Keywords:
non-small cell lung cancer;
sentinel lymph nodes;
methylene blue;
9 mTc-sulfur colloid
- From:
Journal of Southern Medical University
2014;(7):1053-1056
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the accuracy of intaoperative methylene blue alone and in combination with 9 mTc-sulfur colloid isotopic tracing for detection of sentinel lymph nodes (SLNs) in early-stage non-small cell lung cancer (NSCLC). Methods Sixty-one patients with operable NSCLC who did not receive previous radiotherapy or chemotherapy were enrolled. Methylene blue and 9 mTc-sulfur colloid were injected into the subserosal layer adjacent to the tumor, and SLNs were defined as those with blue staining or those containing 3 times more radioactivity than the surrounding tissue detected with a gamma probe. The SLN were removed with systematic lymph node dissection. All the removed lymph nodes were examined histopathologically with HE staining and immunohistochemistry. Results Methylene blue alone showed a low detection rate (60.0%) and sensitivity (58.33%) for SLNs compared with the combination of methylene blue and isotope tracing (96.15%and 92.86%, respectively). Conclusion The combination of methylene blue and 9 mTc-sulfur colloid isotopic tracing allows accurate detection of the SLNs in early-stage NSCLC.
