Pathogenic analysis of severe community-acquired pneumonia in children in Shijiazhuang, Hebei province, 2014-2016
10.3760/cma.j.cn112866-20240605-00092
- VernacularTitle:2014—2016年河北省石家庄地区儿童重症社区获得性肺炎的病原学分析
- Author:
Fei LI
1
;
Shuhua AN
;
Jiayun GUO
;
Qi LI
;
Zhengde XIE
;
Xiangpeng CHEN
Author Information
1. 国家儿童医学中心 首都医科大学附属北京儿童医院 北京市儿科研究所感染与病毒研究室 中国医学科学院儿童危重感染诊治创新单元 国家呼吸系统疾病临床医学研究中心，教育部儿科重大疾病研究重点实验室 儿童呼吸道感染性疾病研究北京市重点实验室，北京 100045
- Keywords:
Severe pneumonia;
Nasopharyngeal swab;
Etiology;
Children
- From:
Chinese Journal of Experimental and Clinical Virology
2024;38(5):513-520
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the etiological distribution of severe community-acquired pneumonia (CAP) in children in Hebei Province.Methods:The nasopharyngeal swab samples and clinical data from 314 children with severe pneumonia were retrospectively analyzed between January 2014 and January 2016.Results:Among the 314 children, 298 (94.94%) showed positive result for pathogens in their nasopharyngeal swab samples, with 246 cases (78.34%) of multiple pathogens, predominantly mixed viruses and bacteria (206 cases, 65.61%). A total of 848 strains of pathogens were detected, including 483 strains (56.96%) of viruses, predominantly respiratory syncytial virus with 97 strains of subtype A and 86 strains of B. Bacteria and atypical pathogens ( Mycoplasma pneumoniae) had 365 strains (43.04%), mainly Streptococcus pneumoniae (220 strains) and Haemophilus influenzae (119 strains). The detection rate of pathogens was higher in children under one year of age ( χ2=21.389, P<0.001). There were no significant differences in different seasons, but the detection rates of respiratory syncytial virus A, respiratory syncytial virus B, and Streptococcus pneumoniae were higher in autumn, winter, and spring, respectively, with statistically significant differences ( χ2=22.205, P<0.001; χ2=37.874, P<0.001; χ2=11.380, P=0.009). Conclusions:Nasopharyngeal swab sample testing in children with severe pneumonia typically shows a coexistence of viral and bacterial pathogens, with detection rates varying among different age groups and seasons. Nasopharyngeal swab sample testing for pathogens provides valuable references for the identification of clinical pathogens.
